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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are often described by their focus on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of standard equipment.

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Pragmatic is a software company, offers a variety of casino games for online gambling platforms. Pragmatic's iGaming solutions are used by the most reputable operators as well as land-based casinos. The company provides front-end tools for design, analysis, promotions, marketing and payment systems, as well as security, customer service and bug reporting. Additionally, the company provides its players a safe and secure environment that features high-quality graphics and gameplay.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and included participants from various geographical areas. This type of heterogeneity which is vital for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However, too much heterogeneity can result in issues with the design of the trial.

Pragmatic Play Pragmatic Play, a major player on the live casino market, offers various classic table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta provide customers with an authentic gambling experience, as well a full variety of betting options via virtual. The company has also created various interactive games to make online gambling fun. Some of these shows are hosted live and others include famous people from the industry.

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Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can also be used to assess the causality of an intervention and its effects. They should not, however be used to replace explanatory studies.

The pragmatism concept is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study, including recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health science community is becoming more acquaint to the issue of pragmatism. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.