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The exact mechanism that allows Zoloft to combat depression, anxiety and OCD is still not completely understood, however what researchers have noticed is that Zoloft affects the way serotonin is managed by the human body. Serotonin is part Normal dose of levothyroxine a drug family known as selective serotonin re-uptake inhibitors (or Normal dose of levothyroxine SSRI's). SSRI's increase the level of serotonin in the brain by inhibiting (not preventing) its breakdown. And yes, while this may seem complicated it really isn't.