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When you've decided to go on medication for Starting metformin dose depression or anxiety, your physician will hopefully give you a few options to choose from. Seroxat and Prozac are among the most popular brand names of SSRI's available in the United States, while Zoloft is arguably the best choice on this list. One hundred percent of patients who have taken this drug have reported feeling relief, and side effects are minimal when compared to other drugs in its class