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Zoloft is taken by people who suffer from depression, Provigil vs adderall anxiety and obsessive-compulsive disorder. It is an antidepressant that works differently than most antidepressants in that it helps to increase the amount of serotonin in the brain instead of decreasing it as most antidepressants do. Because Zoloft has a larger number or Provigil vs adderall side effects than other antidepressants (monitored closely) many doctors prescribe it as their first choice of antidepressant if they believe their patient will respond well to SSRI drugs or if they have experienced some form of "bad reaction" with other antidepressants in their arsenal.